[Biosimilar Darbepoetin Alfa]
Launched in 2014, Derise is our first biosimilar, and we are the second company in the world to launch the Biosimilar Darbepoetin Alfa, for treating anaemia due to chronic kidney failure and chemotherapy-induced anaemia.
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[Biosimilar Rituximab]
Our second biosimilar and the first monoclonal antibody of Hetero Biopharma, Rilast, was launched in 2015. Today, it is being used to treat numerous conditions, including non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukaemia, and Rheumatoid arthritis.
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[Biosimilar Bevacizumab]
Launched in 2016, Bevaas is Hetero’s second monoclonal antibody and the third biosimilar product that offers major relief for conditions such as metastatic colorectal cancer, lung cancer, and renal cancer.
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[Biosimilar Adalimumab]
Our recent offering, Pamera, launched in 2017, is intended for the treatment of various types of autoimmune disorders such as Rheumatoid Arthritis (RA), Psoriatic Arthritis (PA), and Methotrexate Resistant Arthritis (MRA). Adalimumab, the drug it contains, is the world’s largest-selling product.
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[Trastuzumab]
Sezuma contains the active substance trastuzumab, which is a humanized monoclonal antibody that binds to the HER-2 protein. The protein inhibits the proliferation of human tumor cells that overexpress HER-2. Sezuma contains trastuzumab as the active substance along with L-Histidine Hydrochloride Monohydrate, L-Histidine, Trehalose Dihydrate, and Polysorbate 20.
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[Biosimilar Tocilizumab]
Tocilizumab is a recombinant humanized anti-human interleukin 6 (IL-6) receptor monoclonal antibody of the immunoglobulin IgG1κ (gamma 1, kappa) subclass with a typical H2L2 polypeptide structure. Each light chain and heavy chain consists of 214 and 448 amino acids, respectively.
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[Pegaspargase]
Pegaspargase is an enzyme that consists of L-asparagine Amidohydrolase, covalently conjugated to Monomethoxy Polyethylene Glycol (mPEG). L-asparaginase is a tetrameric enzyme produced endogenously by E. Coli and consists of identical 345 kDa subunits.
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[L-Asparaginase]
L-asparaginase for Injection contains the enzyme L-asparaginase Amidohydrolase, type EC-2. Asparaginase is not absorbed from the GI tract and must be administered IM or IV. The IM route maintains efficacy and is not less immunogenic. L-asparaginase activity is expressed in terms of international units according to the recommendations of the International Union of Biochemistry.
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[Tenecteplase]
TNKPLASE (Tenecteplase) is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese Hamster Ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA that is a substitution of threonine 103 with asparagine and a substitution of asparagine 117 with glutamine, both within the kringle one domain and a tetra-alanine substitution at amino acids 296–299 in the protease domain.
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